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1.

A Prize for Cancer Prevention.

Varmus, Harold.

Cell ; 171(1): 14-17, 2017 Sep 21.

Article in English | MEDLINE | ID: mdl-28888324

2.

A Prize for Cancer Prevention.

Varmus, Harold.

Cell ; 171(2): 495, 2017 10 05.

Article in English | MEDLINE | ID: mdl-28985568

3.

The United States needs a department of technology and science policy.

Varmus, Harold; Zerhouni, Elias.

Nature ; 600(7887): 30-32, 2021 12.

Article in English | MEDLINE | ID: mdl-34848863

4.

Threatening the Global AIDS Response - Obstacles to PEPFAR's Reauthorization.

Abdool Karim, Salim S; Barre-Sinoussi, Francoise; Varmus, Harold E; Serwadda, David; Bukusi, Elizabeth; M'boup, Souleymane; Kamarulzaman, Adeeba; Swaminathan, Soumya; Pape, Jean W.

N Engl J Med ; 389(13): 1159-1161, 2023 Sep 28.

Article in English | MEDLINE | ID: mdl-37694893

5.

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.

Fei, Dennis Liang; Zhen, Tao; Durham, Benjamin; Ferrarone, John; Zhang, Tuo; Garrett, Lisa; Yoshimi, Akihide; Abdel-Wahab, Omar; Bradley, Robert K; Liu, Paul; Varmus, Harold.

Proc Natl Acad Sci U S A ; 115(44): E10437-E10446, 2018 10 30.

Article in English | MEDLINE | ID: mdl-30322915

6.

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.

Fan, Pang-Dian; Narzisi, Giuseppe; Jayaprakash, Anitha D; Venturini, Elisa; Robine, Nicolas; Smibert, Peter; Germer, Soren; Yu, Helena A; Jordan, Emmet J; Paik, Paul K; Janjigian, Yelena Y; Chaft, Jamie E; Wang, Lu; Jungbluth, Achim A; Middha, Sumit; Spraggon, Lee; Qiao, Huan; Lovly, Christine M; Kris, Mark G; Riely, Gregory J; Politi, Katerina; Varmus, Harold; Ladanyi, Marc.

Proc Natl Acad Sci U S A ; 115(26): E6030-E6038, 2018 06 26.

Article in English | MEDLINE | ID: mdl-29875142

7.

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.

Fei, Dennis Liang; Motowski, Hayley; Chatrikhi, Rakesh; Prasad, Sameer; Yu, Jovian; Gao, Shaojian; Kielkopf, Clara L; Bradley, Robert K; Varmus, Harold.

PLoS Genet ; 12(10): e1006384, 2016 Oct.

Article in English | MEDLINE | ID: mdl-27776121

8.

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

McFadden, David G; Politi, Katerina; Bhutkar, Arjun; Chen, Frances K; Song, Xiaoling; Pirun, Mono; Santiago, Philip M; Kim-Kiselak, Caroline; Platt, James T; Lee, Emily; Hodges, Emily; Rosebrock, Adam P; Bronson, Roderick T; Socci, Nicholas D; Hannon, Gregory J; Jacks, Tyler; Varmus, Harold.

Proc Natl Acad Sci U S A ; 113(42): E6409-E6417, 2016 10 18.

Article in English | MEDLINE | ID: mdl-27702896

9.

A new initiative on precision medicine.

Collins, Francis S; Varmus, Harold.

N Engl J Med ; 372(9): 793-5, 2015 Feb 26.

Article in English | MEDLINE | ID: mdl-25635347

10.

Rescuing US biomedical research from its systemic flaws.

Alberts, Bruce; Kirschner, Marc W; Tilghman, Shirley; Varmus, Harold.

Proc Natl Acad Sci U S A ; 111(16): 5773-7, 2014 Apr 22.

Article in English | MEDLINE | ID: mdl-24733905

11.

Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.

Jechlinger, Martin; Podsypanina, Katrina; Varmus, Harold.

Genes Dev ; 23(14): 1677-88, 2009 Jul 15.

Article in English | MEDLINE | ID: mdl-19605689

12.

Three decades of Wnts: a personal perspective on how a scientific field developed.

Nusse, Roel; Varmus, Harold.

EMBO J ; 31(12): 2670-84, 2012 Jun 13.

Article in English | MEDLINE | ID: mdl-22617420

13.

Harold Varmus. Interview by Errol C. Friedberg.

Varmus, Harold.

Nat Rev Mol Cell Biol ; 9(7): 502-3, 2008 Jul.

Article in English | MEDLINE | ID: mdl-18578058

14.

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins.

Lockwood, William W; Zejnullahu, Kreshnik; Bradner, James E; Varmus, Harold.

Proc Natl Acad Sci U S A ; 109(47): 19408-13, 2012 Nov 20.

Article in English | MEDLINE | ID: mdl-23129625

15.

Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.

Beverly, Levi J; Lockwood, William W; Shah, Parag P; Erdjument-Bromage, Hediye; Varmus, Harold.

Proc Natl Acad Sci U S A ; 109(3): E119-26, 2012 Jan 17.

Article in English | MEDLINE | ID: mdl-22233804

16.

Toward a Shared Vision for Cancer Genomic Data.

Grossman, Robert L; Heath, Allison P; Ferretti, Vincent; Varmus, Harold E; Lowy, Douglas R; Kibbe, Warren A; Staudt, Louis M.

N Engl J Med ; 375(12): 1109-12, 2016 Sep 22.

Article in English | MEDLINE | ID: mdl-27653561

17.

Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis.

Du, Yi-Chieh Nancy; Chou, Chen-Kung; Klimstra, David S; Varmus, Harold.

Proc Natl Acad Sci U S A ; 108(40): 16753-8, 2011 Oct 04.

Article in English | MEDLINE | ID: mdl-21940500

18.

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Somwar, Romel; Erdjument-Bromage, Hediye; Larsson, Erik; Shum, David; Lockwood, William W; Yang, Guangli; Sander, Chris; Ouerfelli, Ouathek; Tempst, Paul J; Djaballah, Hakim; Varmus, Harold E.

Proc Natl Acad Sci U S A ; 108(39): 16375-80, 2011 Sep 27.

Article in English | MEDLINE | ID: mdl-21930909

19.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation.

Gardner, Eric E; Earlie, Ethan M; Li, Kate; Thomas, Jerin; Hubisz, Melissa J; Stein, Benjamin D; Zhang, Chen; Cantley, Lewis C; Laughney, Ashley M; Varmus, Harold.

Science ; 383(6683): eadj1415, 2024 Feb 09.

Article in English | MEDLINE | ID: mdl-38330136

20.

Science funding: Provocative questions in cancer research.

Varmus, Harold; Harlow, Ed.

Nature ; 481(7382): 436-7, 2012 Jan 25.

Article in English | MEDLINE | ID: mdl-22281578

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A Prize for Cancer Prevention.

A Prize for Cancer Prevention.

The United States needs a department of technology and science policy.

Threatening the Global AIDS Response - Obstacles to PEPFAR's Reauthorization.

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

A new initiative on precision medicine.

Rescuing US biomedical research from its systemic flaws.

Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.

Three decades of Wnts: a personal perspective on how a scientific field developed.

Harold Varmus. Interview by Errol C. Friedberg.

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins.

Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.

Toward a Shared Vision for Cancer Genomic Data.

Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis.

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation.

Science funding: Provocative questions in cancer research.